Cancer is undoubtedly one of the main health concerns facing our society and one of the primary targets regarding medicinal chemistry. Even though platinum-based complexes had been in primary focus of research on chemotherapy agents, the interests in this field have shifted to non-platinumbased agents in order to find different metal complexes with less side effects and similar, or better, cytotoxicity. Thus, a wide variety of metal complexes based on titanium, gallium, germanium, palladium, gold, cobalt, ruthenium and tin are being intensively studied as platinum replacements . Furthermore, copper(II)-based complexes appear to be very promising candidates for anticancer therapy; an idea supported by a considerable number of research articles describing the synthesis and cytotoxic activities of numerous copper(II) complexes.The choice of the coordinated ligand(s) seems to be as important as the choice of metal(s) because besides being the integral part of biologically active complexes these organic molecules (ligands) can exert a biological activity of their own. Complexes incorporating 3-hydroxy-5-hydroxymethyl-2- methylpyridine-4-carboxaldehyde-3-methylisotiosemicarbazone (pyridoxal-thiosemicarbazone or PLTSC) ligand have not only been in focus of anticancer research in past several years but also an inspiration for the synthesis of a new ligand .
Dr. Rambabu Gundla, presently holding Head of Chemistry department and Professor at GITAM University, Hyderabad since 2014. His major research focused on "Discovery and Development of Biologically Active Compounds" such as anti-inflammatory, anti-viral and anti-cancer anti-diabetic agents. He was a postdoctoral research fellow in the department of pharmacology and pharmaceutical Sciences, school of pharmacy, at the University of Southern California, USA from 2006 - 2008. He obtained a Ph.D. degree from the department of chemistry, Osmania University, Hyderabad, India, in 2006. From 2001 to 2006, he worked as a research scientist at GVK Biosciences Private Limited, Hyderabad, India. After completion his postdoctoral research fellow, he again joined as a Principal Scientist at GVKBIO (2008-2014). He has a more than 75 publications in National and International Journals and 3 patents in the area of medicinal chemistry and computer-aided drug design..
Dr.Kalyani Paidikondala working as Asst.prof of Chemistry in Gandhi Institute of Technology and Management Hyderabad, INDIA. Earlier she has worked as Research Scientist in Arches laboratories Hyderabad from 2012-2017. She has published various 23 research papers in various International and National journals. She is awarded PhD degree on “Synthesis Characterization Anticancer Activity of Quercetin Curcumin Derivatives and their Complexes” in Jawaharlal Nehru Technological University Hyderabad. She has attended and presented her research papers in national and international conferences. She is Author of three books - “Spectroscopy & Anti Cancer Activity of Quercetin And Curcumin Complexes”, “Gold and Platinum complexes as anti cancer drugs” and Palladium, Ruthenium And Rhodium Complexes As Chemotherapeutic Agents. Her research interests are synthesis of anti cancer agents, Environmental chemistry and Applied chemistry.
Prof. Prakash Kinthada is currently Professor and Head, of Department of Chemistry at NIMS University Jaipur, rajasthan. Earlier he was Professor and Head, Department of Chemistry at Sri Vidyaniketan Engineering College, Tirupati. Prior to that he was an Associate Professor at Gitam University, Visakhapatnam. He recently returned from USA where he was a NIH visiting fellow at Karmonas cancer research center, Michigan, USA. Earlier to that he was a royal society visiting fellow at Oxford University, Oxford, UK. Prior to that he was a leverhulme visiting fellow at Aston University, Birmingham, UK. Before that he was a Nehru British fellow at Imperial College of Science Technology and Medicine London, UK. He has 40 international publications. He has presented more than 100 presentations at international conferences including American chemical society conferences. He is an editorial board member of more than 120 international journals. He is the author of three books, including one by Lambert publishers, Germany.